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KPNA6 is a Cofactor of ANP32A/B in Supporting Influenza Virus Polymerase Activity

Authors: Mengmeng Yu; Liuke Sun; Zhenyu Zhang; Yuan Zhang; Haili Zhang; Lei Na; Xiaojun Wang;

KPNA6 is a Cofactor of ANP32A/B in Supporting Influenza Virus Polymerase Activity

Abstract

Host factor ANP32 plays a fundamental role in supporting the polymerase activity of influenza viruses, but the underlying mechanism is largely unknown. Here, we propose that KPNA6 is involved in the function of ANP32A/B to support influenza virus polymerase by interacting with both vRNP and ANP32A/B.

Related Organizations
Keywords

Cell Nucleus, alpha Karyopherins, KPNA6, Nuclear Proteins, RNA-Binding Proteins, Genome, Viral, Orthomyxoviridae, RNA-Dependent RNA Polymerase, Virus Replication, Microbiology, QR1-502, vRNP, polymerase, Viral Proteins, HEK293 Cells, Influenza A virus, Animals, Humans, ANP32A, ANP32B, influenza, Research Article

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    7
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
Powered by OpenAIRE graph
citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
7
Top 10%
Average
Top 10%
Green
gold