Direct interaction and cooperative role of tumor suppressor p16 with band 3 (AE1)
Copyright policy )Direct interaction and cooperative role of tumor suppressor p16 with band 3 (AE1)
By using the C‐terminal 112‐residue of band 3 to screen the K562 cDNA library, we find that the p16 interacts with band 3, which was confirmed both in yeast and in mammalian cells. Functional experiments show that p16 facilitates the movement of band 3 to plasma membrane with increased anion transport activity in 293t cells. Moreover, expression of endogenous p16 in 293t cells was increased at 24 and 36 h after transfection with band 3. Our findings provide a novel regulation pathway for both band 3 and p16.
- Chinese Academy of Sciences China (People's Republic of)
- Chinese Academy of Sciences (中国科学院) China (People's Republic of)
- Chinese Academy of Science (中国科学院) China (People's Republic of)
- Shanghai University China (People's Republic of)
- Shanghai Institutes for Biological Sciences China (People's Republic of)
Anion exchanger, Blotting, Western, Molecular Sequence Data, p16, Immunohistochemistry, Anion transport activity, Cell Line, Band 3, Anion Exchange Protein 1, Erythrocyte, Two-Hybrid System Techniques, Humans, Immunoprecipitation, Amino Acid Sequence, Cyclin-Dependent Kinase Inhibitor p16, Protein Binding
Anion exchanger, Blotting, Western, Molecular Sequence Data, p16, Immunohistochemistry, Anion transport activity, Cell Line, Band 3, Anion Exchange Protein 1, Erythrocyte, Two-Hybrid System Techniques, Humans, Immunoprecipitation, Amino Acid Sequence, Cyclin-Dependent Kinase Inhibitor p16, Protein Binding
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).23 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!