The ubiquitin-specific protease USP28 is required for MYC stability
Copyright policy )The ubiquitin-specific protease USP28 is required for MYC stability
The MYC proto-oncogene encodes a transcription factor that has been implicated in the genesis of many human tumours. Here, we used a bar-code short hairpin RNA (shRNA) screen to identify multiple genes that are required for MYC function. One of these genes encodes USP28, an ubiquitin-specific protease. USP28 is required for MYC stability in human tumour cells. USP28 binds to MYC through an interaction with FBW7alpha, an F-box protein that is part of an SCF-type ubiquitin ligase. Therefore, it stabilizes MYC in the nucleus, but not in the nucleolus, where MYC is degraded by FBW7gamma. High expression levels of USP28 are found in colon and breast carcinomas, and stabilization of MYC by USP28 is essential for tumour-cell proliferation.
- Netherlands Heart Institute Netherlands
- Harvard University United States
- Philipps-University of Marburg Germany
- Antoni van Leeuwenhoek Hospital Netherlands
Cell Nucleus, SKP Cullin F-Box Protein Ligases, F-Box Proteins, Carcinoma, Ductal, Breast, Liver Neoplasms, Breast Neoplasms, Adenocarcinoma, Proto-Oncogene Mas, Proto-Oncogene Proteins c-myc, Cell Line, Tumor, Colonic Neoplasms, Humans, Ubiquitin Thiolesterase, Cell Nucleolus, Cell Proliferation
Cell Nucleus, SKP Cullin F-Box Protein Ligases, F-Box Proteins, Carcinoma, Ductal, Breast, Liver Neoplasms, Breast Neoplasms, Adenocarcinoma, Proto-Oncogene Mas, Proto-Oncogene Proteins c-myc, Cell Line, Tumor, Colonic Neoplasms, Humans, Ubiquitin Thiolesterase, Cell Nucleolus, Cell Proliferation
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).419 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!