Identification of two new HLA‐A alleles, A*2419 and A*3011, by sequence‐based typing
Copyright policy )Identification of two new HLA‐A alleles, A*2419 and A*3011, by sequence‐based typing
Abstract: In this report, we describe two new HLA‐A alleles, A*2419 and A* 3011, that were initially recognized by an aberrant serological pattern. Sequence‐based typing revealed sequence differences with other known HLA‐A alleles. Allele A*2419 showed 4 nucleotide differences with A*2404, resulting in 4 amino acid differences at codons 70, 76, 77 and 90. Compared with other A*24 alleles, A*2419 lacks the Bw4 motif, as do A*2404 and A*2428. The A*3011 allele showed 2 mismatches with A*3001, resulting in one amino acid difference at codon 80.
- Maastricht University Netherlands
Base Sequence, HLA-A Antigens, Histocompatibility Testing, Sequence Homology, Nucleic Acid, Molecular Sequence Data, Humans, Sequence Analysis, DNA, Polymerase Chain Reaction, Alleles
Base Sequence, HLA-A Antigens, Histocompatibility Testing, Sequence Homology, Nucleic Acid, Molecular Sequence Data, Humans, Sequence Analysis, DNA, Polymerase Chain Reaction, Alleles
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