Association of transient receptor potential canonical type 3 (TRPC3) channel transcripts with proinflammatory cytokines
Copyright policy )Association of transient receptor potential canonical type 3 (TRPC3) channel transcripts with proinflammatory cytokines
We investigated whether expression of non-selective cation channels of the transient receptor potential canonical (TRPC) channel family are associated with proinflammatory cytokines in monocytes. Using quantitative RT-PCR we studied the expression of TRPC3, interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha) in monocytes from 15 patients with essential hypertension and 16 age- and sex-matched normotensive control subjects. We observed an approximately 8-fold increase of TRPC3 transcripts in monocytes from patients with essential hypertension compared to normotensive control subjects (p<0.05). We found an approximately 3-fold increase of IL-1beta, and an approximately 9-fold increase of TNF-alpha in patients with essential hypertension compared to normotensive control subjects (each p<0.05). We observed a significant correlation between TRPC3 transcripts with systolic blood pressure, expression of IL-1beta, and TNF-alpha. Using quantitative RT-PCR we observed an association of TRPC3 transcripts and proinflammatory cytokines in monocytes.
- Charité - University Medicine Berlin Germany
- University of Southern Denmark Denmark
Male, Transcription, Genetic, Tumor Necrosis Factor-alpha, Messenger, Interleukin-1beta, Middle Aged, Monocytes, Genetic, Hypertension, RNA, Cytokines, Humans, Female, RNA, Messenger, Inflammation Mediators, Transcription, Aged, TRPC Cation Channels
Male, Transcription, Genetic, Tumor Necrosis Factor-alpha, Messenger, Interleukin-1beta, Middle Aged, Monocytes, Genetic, Hypertension, RNA, Cytokines, Humans, Female, RNA, Messenger, Inflammation Mediators, Transcription, Aged, TRPC Cation Channels
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