Role of CD8+ and CD4+ T cells in the rejection of murine intestinal allografts
Copyright policy )Role of CD8+ and CD4+ T cells in the rejection of murine intestinal allografts
A MAJOR factor preventing the more widespread clinical application of intestinal transplantation is the unusual frequency and severity of allograft rejection. Using a murine model of intestinal transplantation, we have previously shown that allograft rejection was dependent on ab, but not gd, T cells and that this rejection could be significantly inhibited by tacrolimus, an immunosuppressive agent with potent anti-T-cell properties. In this study, the murine model was used to examine further the role of CD8 and CD4 T cells in the rejection of intestinal allografts.
- University of Chicago United States
CD4-Positive T-Lymphocytes, Graft Rejection, Immunosuppression Therapy, Mice, Knockout, Genes, MHC Class II, Histocompatibility Antigens Class I, Histocompatibility Antigens Class II, Antibodies, Monoclonal, Genes, MHC Class I, Mice, Inbred Strains, CD8-Positive T-Lymphocytes, Lymphocyte Depletion, Mice, Inbred C57BL, Mice, Transplantation, Isogeneic, Intestine, Small, Animals, Transplantation, Homologous
CD4-Positive T-Lymphocytes, Graft Rejection, Immunosuppression Therapy, Mice, Knockout, Genes, MHC Class II, Histocompatibility Antigens Class I, Histocompatibility Antigens Class II, Antibodies, Monoclonal, Genes, MHC Class I, Mice, Inbred Strains, CD8-Positive T-Lymphocytes, Lymphocyte Depletion, Mice, Inbred C57BL, Mice, Transplantation, Isogeneic, Intestine, Small, Animals, Transplantation, Homologous
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