The RNA–Methyltransferase Misu (NSun2) Poises Epidermal Stem Cells to Differentiate
Copyright policy )The RNA–Methyltransferase Misu (NSun2) Poises Epidermal Stem Cells to Differentiate
Homeostasis of most adult tissues is maintained by balancing stem cell self-renewal and differentiation, but whether post-transcriptional mechanisms can regulate this process is unknown. Here, we identify that an RNA methyltransferase (Misu/Nsun2) is required to balance stem cell self-renewal and differentiation in skin. In the epidermis, this methyltransferase is found in a defined sub-population of hair follicle stem cells poised to undergo lineage commitment, and its depletion results in enhanced quiescence and aberrant stem cell differentiation. Our results reveal that post-transcriptional RNA methylation can play a previously unappreciated role in controlling stem cell fate.
- Medical Research Council United Kingdom
- Wellcome Trust United Kingdom
- Cancer Research UK United Kingdom
- Institució Catalana de Recerca i Estudis Avançats Spain
- Wellcome / MRC Cambridge Stem Cell Institute United Kingdom
Keratinocytes, RNA Processing, 570, Lymphoid Enhancer-Binding Factor 1, Post-Transcriptional, 610, Embryonic Development, Mice, Transgenic, QH426-470, Methylation, Transgenic, Mice, RNA, Transfer, Genetics, Animals, Homeostasis, RNA Processing, Post-Transcriptional, beta Catenin, Stem Cells, Body Weight, Cell Differentiation, Methyltransferases, Transfer, Epidermal Cells, RNA, Epidermis, Hair Follicle, Research Article
Keratinocytes, RNA Processing, 570, Lymphoid Enhancer-Binding Factor 1, Post-Transcriptional, 610, Embryonic Development, Mice, Transgenic, QH426-470, Methylation, Transgenic, Mice, RNA, Transfer, Genetics, Animals, Homeostasis, RNA Processing, Post-Transcriptional, beta Catenin, Stem Cells, Body Weight, Cell Differentiation, Methyltransferases, Transfer, Epidermal Cells, RNA, Epidermis, Hair Follicle, Research Article
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