Interaction between Calpain-5, Peroxisome proliferator-activated receptor-gamma and Peroxisome proliferator-activated receptor-delta genes: a polygenic approach to obesity.
Copyright policy )Interaction between Calpain-5, Peroxisome proliferator-activated receptor-gamma and Peroxisome proliferator-activated receptor-delta genes: a polygenic approach to obesity.
Obesity is a multifactorial disorder, that is, a disease determined by the combined effect of genes and environment. In this context, polygenic approaches are needed.To investigate the possibility of the existence of a crosstalk between the CALPAIN 10 homologue CALPAIN 5 and nuclear receptors of the peroxisome proliferator-activated receptors family.Cross-sectional, genetic association study and gene-gene interaction analysis.The study sample comprise 1953 individuals, 725 obese (defined as body mass index > or = 30) and 1228 non obese subjects.In the monogenic analysis, only the peroxisome proliferator-activated receptor delta (PPARD) gene was associated with obesity (OR = 1.43 [1.04-1.97], p = 0.027). In addition, we have found a significant interaction between CAPN5 and PPARD genes (p = 0.038) that reduces the risk for obesity in a 55%.Our results suggest that CAPN5 and PPARD gene products may also interact in vivo.
- Hospital Clínico San Carlos Spain
- Hospital Universitario de Valme Spain
- Comunidad de Madrid Spain
- Hospital Universitario de Valme Spain
Polymorphism, Genetic, Genotype, Calpain, Endocrinology, Diabetes and Metabolism, PPAR gamma, Cross-Sectional Studies, Gene Frequency, RC666-701, Diseases of the circulatory (Cardiovascular) system, Humans, Obesity, PPAR delta, Cardiology and Cardiovascular Medicine, Original Investigation
Polymorphism, Genetic, Genotype, Calpain, Endocrinology, Diabetes and Metabolism, PPAR gamma, Cross-Sectional Studies, Gene Frequency, RC666-701, Diseases of the circulatory (Cardiovascular) system, Humans, Obesity, PPAR delta, Cardiology and Cardiovascular Medicine, Original Investigation
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