Characterization of a novel HLA‐Cw*02 variant, Cw*0208, in a Caucasian individual
Copyright policy )Characterization of a novel HLA‐Cw*02 variant, Cw*0208, in a Caucasian individual
Abstract: We describe an additional HLA‐Cw*02 variant, HLA‐Cw*0208, which has been identified in a renal transplant recipient of Caucasian origin (Italy). After performing preliminary serological typing, we analyzed exons 2 and 3 of the HLA‐C locus polymorphism by cloning the amplified DNA and using a sequence‐based typing method. The new allele differs from Cw*020202 by one nucleotide substitution at nucleotide 61 (G→A) of exon 2, which translates to a difference of one amino acid at residue 21 (His→Arg) of the HLA‐C heavy chain. We propose that Cw*0208 was generated by a random point mutation in codon 21 from the Cw*020202 allele, or through gene conversion of Cw*020202 with another allele, probably the Cw*1205 and Cw*1602 alleles.
- National Research Council Italy
- University of L'Aquila Italy
HLA-C; HLA-Cw*0208; new alleles; polymorph-ism; sequence-based typing; transplantation, Polymorphism, Genetic, Base Sequence, Sequence Homology, Amino Acid, Histocompatibility Testing, Molecular Sequence Data, Exons, HLA-C Antigens, Kidney Transplantation, Protein Structure, Secondary, Sequence Homology, Nucleic Acid, Humans, Point Mutation, Amino Acid Sequence, Amino Acids, Alleles
HLA-C; HLA-Cw*0208; new alleles; polymorph-ism; sequence-based typing; transplantation, Polymorphism, Genetic, Base Sequence, Sequence Homology, Amino Acid, Histocompatibility Testing, Molecular Sequence Data, Exons, HLA-C Antigens, Kidney Transplantation, Protein Structure, Secondary, Sequence Homology, Nucleic Acid, Humans, Point Mutation, Amino Acid Sequence, Amino Acids, Alleles
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).4 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!