Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development
Copyright policy )Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development
The transcription factor SCL/tal-1 is essential for blood cell development. Though it is also expressed in vascular endothelium, SCL has been considered dispensable for vessel formation. Through transgenic rescue of hematopoietic defects of SCL-/- embryos and analysis of chimeras generated with SCL-/- ES cells tagged with a transgene expressed in vascular endothelial cells, we show that SCL is essential for angiogenic remodeling of the yolk sac capillary network into complex vitelline vessels. These findings establish a role for SCL in embryonic angiogenesis and argue for critical functions in both embryonic blood and vascular cells, the descendents of the presumptive hemangioblast.
- Harvard University United States
- Howard Hughes Medical Institute United States
RNA, Untranslated, Recombinant Fusion Proteins, Models, Cardiovascular, Neovascularization, Physiologic, Proteins, Receptor Protein-Tyrosine Kinases, Mice, Transgenic, Receptor, TIE-2, Hematopoiesis, DNA-Binding Proteins, Mice, Proto-Oncogene Proteins, Basic Helix-Loop-Helix Transcription Factors, Animals, Endothelium, Vascular, Vitelline Membrane, Cell Division, T-Cell Acute Lymphocytic Leukemia Protein 1, Transcription Factors, Yolk Sac
RNA, Untranslated, Recombinant Fusion Proteins, Models, Cardiovascular, Neovascularization, Physiologic, Proteins, Receptor Protein-Tyrosine Kinases, Mice, Transgenic, Receptor, TIE-2, Hematopoiesis, DNA-Binding Proteins, Mice, Proto-Oncogene Proteins, Basic Helix-Loop-Helix Transcription Factors, Animals, Endothelium, Vascular, Vitelline Membrane, Cell Division, T-Cell Acute Lymphocytic Leukemia Protein 1, Transcription Factors, Yolk Sac
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