HLA‐DRB1*0826 and HLA‐DQB1*0627, two novel class II alleles identified in blood stem cell donors of Caucasian origin
Copyright policy )HLA‐DRB1*0826 and HLA‐DQB1*0627, two novel class II alleles identified in blood stem cell donors of Caucasian origin
AbstractThis report describes two novel HLA class II alleles, HLA‐DRB1*0826 and HLA‐DQB1*0627, that have been identified in two unrelated voluntary blood stem cell donors of Caucasian origin. HLA‐DRB1*0826 is characterized by a nucleotide substitution (G to T) in exon 2 at position 163, leading to an amino acid exchange from argenine to leucine. The donor phenotype is HLA‐A*0301,*2902; B*3501,*4403; Cw*0401,*1601; DRB1*0101,*0826; DQB1*0402, *0501. The HLA‐DQB1*0627 alleles contain a nucleotide substitution at position 184 (T to C) resulting in an amino acid exchange from tyrosine to histidine. Family segregation analysis revealed that the HLA‐DQB1*0627 allele belongs to the haplotype A*0101, B*1517, Cw*0701, DRB1*1302, DQB1*0627. The donor phenotype is HLA‐A*0101; B*0801,*1517; Cw*0701; DRB1*1302,*1501; DQB1*0602,*0627.
- Goethe University Frankfurt Germany
- University Hospital Magdeburg Germany
- Otto-von-Guericke University Magdeburg Germany
Membrane Glycoproteins, Base Sequence, Stem Cells, Molecular Sequence Data, Histocompatibility Antigens Class II, Blood Donors, HLA-DR Antigens, White People, Pedigree, Gene Frequency, Haplotypes, HLA-DQ Antigens, Sequence Homology, Nucleic Acid, HLA-DQ beta-Chains, Humans, Alleles, HLA-DRB1 Chains
Membrane Glycoproteins, Base Sequence, Stem Cells, Molecular Sequence Data, Histocompatibility Antigens Class II, Blood Donors, HLA-DR Antigens, White People, Pedigree, Gene Frequency, Haplotypes, HLA-DQ Antigens, Sequence Homology, Nucleic Acid, HLA-DQ beta-Chains, Humans, Alleles, HLA-DRB1 Chains
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