descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2010 English Publisher:Elsevier BVJournal:Structure, volume 18, pages 419-421 (issn: 0969-2126,

Authors: Völler, Daniel; Schindelin, Hermann;

doi: 10.1016/j.str.2010.03.005

pmid: 20399179

And Yet It Moves: Active Site Remodeling in the SUMO E1

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Abstract

The activation of ubiquitin and ubiquin-like proteins is catalyzed by E1 enzymes via consecutive adenylation and thioesterification reactions involving two apparently distant active sites. Olsen et al. (2010) uncover dramatic conformational changes in the SUMO E1 that spatially merge the adenylation and thioesterification active sites, including a > 30 A movement of the active site cysteine.

Related Organizations

University of Würzburg
Germany

Keywords

Structural Biology, Molecular Biology

1 Research products, page 1 of 1

Active site remodelling accompanies thioester bond formation in the SUMO E1
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And Yet It Moves: Active Site Remodeling in the SUMO E1

And Yet It Moves: Active Site Remodeling in the SUMO E1

1 Research products, page 1 of 1

Active site remodelling accompanies thioester bond formation in the SUMO E1