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Article . 2000 . Peer-reviewed
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Science
Article . 2000
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Wnt Signaling in Oncogenesis and Embryogenesis--a Look Outside the Nucleus

Authors: Paul Polakis; Mark Peifer;

Wnt Signaling in Oncogenesis and Embryogenesis--a Look Outside the Nucleus

Abstract

The Wnt cell-cell signaling pathway plays a critical and evolutionarily conserved role in directing cell fates during embryogenesis. In addition, inappropriate activation of the Wnt signal transduction pathway plays a role in a variety of human cancers. Many recent studies of Wnt signaling have provided mechanistic insight into these dual roles. Here we focus on two areas of rapid advance: (i) the machinery that regulates the stability of the key signal transducer, β-catenin, and (ii) the effect of Wnt signaling on cellular targets outside the nucleus, the actin and microtubule cytoskeletons.

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Keywords

Cell Nucleus, Embryo, Nonmammalian, Adenomatous Polyposis Coli Protein, Embryonic Development, Proteins, Zebrafish Proteins, Repressor Proteins, Wnt Proteins, Cytoskeletal Proteins, Embryonic and Fetal Development, Axin Protein, Neoplasms, Proto-Oncogene Proteins, Trans-Activators, Animals, Humans, Cytoskeleton, beta Catenin, Body Patterning, Signal Transduction

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1K
Top 1%
Top 0.1%
Top 0.1%
Related to Research communities
Cancer Research