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Wnt Signaling in Oncogenesis and Embryogenesis--a Look Outside the Nucleus

pmid: 10733430
Wnt Signaling in Oncogenesis and Embryogenesis--a Look Outside the Nucleus
The Wnt cell-cell signaling pathway plays a critical and evolutionarily conserved role in directing cell fates during embryogenesis. In addition, inappropriate activation of the Wnt signal transduction pathway plays a role in a variety of human cancers. Many recent studies of Wnt signaling have provided mechanistic insight into these dual roles. Here we focus on two areas of rapid advance: (i) the machinery that regulates the stability of the key signal transducer, β-catenin, and (ii) the effect of Wnt signaling on cellular targets outside the nucleus, the actin and microtubule cytoskeletons.
- GENENTECH INC United States
- University of North Carolina at Chapel Hill United States
Cell Nucleus, Embryo, Nonmammalian, Adenomatous Polyposis Coli Protein, Embryonic Development, Proteins, Zebrafish Proteins, Repressor Proteins, Wnt Proteins, Cytoskeletal Proteins, Embryonic and Fetal Development, Axin Protein, Neoplasms, Proto-Oncogene Proteins, Trans-Activators, Animals, Humans, Cytoskeleton, beta Catenin, Body Patterning, Signal Transduction
Cell Nucleus, Embryo, Nonmammalian, Adenomatous Polyposis Coli Protein, Embryonic Development, Proteins, Zebrafish Proteins, Repressor Proteins, Wnt Proteins, Cytoskeletal Proteins, Embryonic and Fetal Development, Axin Protein, Neoplasms, Proto-Oncogene Proteins, Trans-Activators, Animals, Humans, Cytoskeleton, beta Catenin, Body Patterning, Signal Transduction
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