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Slit Proteins Prevent Midline Crossing and Determine the Dorsoventral Position of Major Axonal Pathways in the Mammalian Forebrain
Copyright policy )NIH| GENETIC REGULATION OF TELENCEPHALON DEVELOPMENT ,
NIH| NKX HOMEOBOX GENE REGULATION OF VENTRAL CNS DEVELOPMENT ,
NIH| Genetic Regulation of Telencephalon Development
Bagri, A.; Marín Parra, Óscar; Plump, A. S.; Mak, Y.; Pleasure, S. J.; Rubenstein, J. L. R.; Tessier-Lavigne, Marc;
Slit Proteins Prevent Midline Crossing and Determine the Dorsoventral Position of Major Axonal Pathways in the Mammalian Forebrain
We report that Slit proteins, a family of secreted chemorepellents, are crucial for the proper development of several major forebrain tracts. Mice deficient in Slit2 and, even more so, mice deficient in both Slit1 and Slit2 show significant axon guidance errors in a variety of pathways, including corticofugal, callosal, and thalamocortical tracts. Analysis of multiple pathways suggests several generalizations regarding the functions of Slit proteins in the brain, which appear to contribute to (1) the maintenance of dorsal position by prevention of axonal growth into ventral regions, (2) the prevention of axonal extension toward and across the midline, and (3) the channeling of axons toward particular regions.
- University of California, San Francisco United States
- Howard Hughes Medical Institute United States
- Langley Porter Psychiatric Hospital and Clinics United States
- Department of Neurology University of California United States
- Spanish National Research Council Spain
Telencephalon, Serotonin, Neuroscience(all), Dopamine, Nerve Tissue Proteins, Synaptic Transmission, Corpus Callosum, Embryonic and Fetal Development, Mice, Nerve Fibers, Prosencephalon, Mammalian Forebrain, Mesencephalon, Neural Pathways, Slit2, Animals, Receptors, Immunologic, Cerebral Cortex, Afferent Pathways, Axon guidance, Axons, Mice, Mutant Strains, Mutation, Intercellular Signaling Peptides and Proteins
Telencephalon, Serotonin, Neuroscience(all), Dopamine, Nerve Tissue Proteins, Synaptic Transmission, Corpus Callosum, Embryonic and Fetal Development, Mice, Nerve Fibers, Prosencephalon, Mammalian Forebrain, Mesencephalon, Neural Pathways, Slit2, Animals, Receptors, Immunologic, Cerebral Cortex, Afferent Pathways, Axon guidance, Axons, Mice, Mutant Strains, Mutation, Intercellular Signaling Peptides and Proteins
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).370 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1% views 41 - 41views
citations
Citations provided by BIP!
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citations provided by BIP!popularityPopularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Popularity provided by BIP!influenceInfluence provided by BIP!
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Influence provided by BIP!impulseImpulse provided by BIP!
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
Impulse provided by BIP!viewsViews provided by UsageCounts
Views provided by UsageCounts 370
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