Lung tissue regeneration after induced injury in Runx3 KO mice
Copyright policy )Lung tissue regeneration after induced injury in Runx3 KO mice
Runx3 is essential for normal murine lung development, and Runx3 knockout (KO) mice, which die soon after birth, exhibit alveolar hyperplasia. Wound healing, tissue repair, and regeneration mechanisms are necessary in humans for proper early lung development. Previous studies have reported that various signaling molecules, such as pErk, Tgf-beta1, CCSP, pJnk, Smad3, and HSP70 are closely related to wound healing. In order to confirm the relationship between lung defects caused by the loss of function of Runx3 and wound healing, we have localized various wound-healing markers after laser irradiation in wild-type and in Runx3 KO mouse lungs at post-natal day 1. Our results indicate that pERK, Tgf-beta1, CCSP, pJnk, and HSP70 are dramatically down-regulated by loss of Runx3 during lung wound healing. However, Smad3 is up-regulated in the Runx3 KO laser-irradiated lung region. Therefore, the lung wound-healing mechanism is inhibited in the Runx3 KO mouse, which shows abnormal lung architecture, by reduced pErk, Tgf-beta1, CCSP, pJnk, and HSP70 and by induced Smad3.
- University of Hong Kong China (People's Republic of)
- Chungbuk National University Korea (Republic of)
- University of Hong Kong (香港大學) China (People's Republic of)
- Yonsei University Korea (Republic of)
- Yonsei University Health System Korea (Republic of)
Core Binding Factor Alpha 3 Subunit/genetics*, Lung/metabolism, Experimental/rehabilitation, Transforming Growth Factor beta1/genetics, Inbred C57bl, Inbred C57BL, Lung/radiation effects, Hsp70, Core Binding Factor Alpha 3 Subunit - Genetics, Radiation Injuries, Experimental - Pathology - Physiopathology - Rehabilitation, Mice, Wound Healing/physiology, Models, Transforming Growth Factor beta, Lung/physiology*, Transforming Growth Factor Beta1 - Genetics - Metabolism, Experimental/pathology, Regeneration - Genetics - Physiology, Lung Injury/genetics, Lung, HSP70, Smad3 Protein - Genetics - Metabolism, Cells, Cultured, Wound Healing - Genetics - Physiology, Mice, Knockout, Cultured, Smad3 Protein/genetics, Mouse (Runx3 Knockout), Transforming Growth Factor Beta - Genetics - Metabolism, Lung Injury, Smad3 Protein/metabolism, Lung Injury/physiopathology, Lung Injury/pathology, Radiation Injuries, Experimental, Transforming Growth Factor beta1/metabolism, CCSP, PJnk, Lung Injury - Genetics - Pathology - Physiopathology - Rehabilitation, Signal Transduction - Genetics, Transforming Growth Factor beta/metabolism, Signal Transduction, PErk, Transforming Growth Factor beta/genetics, Cells, Knockout, Lung/pathology, Lung Injury/rehabilitation*, Wound healing, 610, Tgf-Β1, Models, Biological, Transforming Growth Factor beta1, Organ Culture Techniques, Runx3 KO, Pjnk, Ccsp, Animals, Regeneration, Smad3 Protein, Radiation Injuries, Perk, Wound Healing, Regeneration/physiology*, Lasers, Experimental - Pathology - Physiopathology - Rehabilitation, Wound Healing/genetics, Tgf-β1, Biological, Lung - Metabolism - Pathology - Physiology - Radiation Effects, Experimental/physiopathology, Mice, Inbred C57bl, Mice, Inbred C57BL, Mouse (Runx3 knockout), Core Binding Factor Alpha 3 Subunit, Runx3 Ko, Signal Transduction/genetics, Regeneration/genetics, Smad3
Core Binding Factor Alpha 3 Subunit/genetics*, Lung/metabolism, Experimental/rehabilitation, Transforming Growth Factor beta1/genetics, Inbred C57bl, Inbred C57BL, Lung/radiation effects, Hsp70, Core Binding Factor Alpha 3 Subunit - Genetics, Radiation Injuries, Experimental - Pathology - Physiopathology - Rehabilitation, Mice, Wound Healing/physiology, Models, Transforming Growth Factor beta, Lung/physiology*, Transforming Growth Factor Beta1 - Genetics - Metabolism, Experimental/pathology, Regeneration - Genetics - Physiology, Lung Injury/genetics, Lung, HSP70, Smad3 Protein - Genetics - Metabolism, Cells, Cultured, Wound Healing - Genetics - Physiology, Mice, Knockout, Cultured, Smad3 Protein/genetics, Mouse (Runx3 Knockout), Transforming Growth Factor Beta - Genetics - Metabolism, Lung Injury, Smad3 Protein/metabolism, Lung Injury/physiopathology, Lung Injury/pathology, Radiation Injuries, Experimental, Transforming Growth Factor beta1/metabolism, CCSP, PJnk, Lung Injury - Genetics - Pathology - Physiopathology - Rehabilitation, Signal Transduction - Genetics, Transforming Growth Factor beta/metabolism, Signal Transduction, PErk, Transforming Growth Factor beta/genetics, Cells, Knockout, Lung/pathology, Lung Injury/rehabilitation*, Wound healing, 610, Tgf-Β1, Models, Biological, Transforming Growth Factor beta1, Organ Culture Techniques, Runx3 KO, Pjnk, Ccsp, Animals, Regeneration, Smad3 Protein, Radiation Injuries, Perk, Wound Healing, Regeneration/physiology*, Lasers, Experimental - Pathology - Physiopathology - Rehabilitation, Wound Healing/genetics, Tgf-β1, Biological, Lung - Metabolism - Pathology - Physiology - Radiation Effects, Experimental/physiopathology, Mice, Inbred C57bl, Mice, Inbred C57BL, Mouse (Runx3 knockout), Core Binding Factor Alpha 3 Subunit, Runx3 Ko, Signal Transduction/genetics, Regeneration/genetics, Smad3
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).7 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!