Molecular cloning and tissue‐specific expression of mouse kidney 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase
Copyright policy )Molecular cloning and tissue‐specific expression of mouse kidney 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase
A 1932 bp cDNA clone encoding a novel isozyme of 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase (PFK‐2/FBPase‐2) was isolated from a mouse kidney cDNA library. The sequence encodes 519 amino acids and, based on homology to rat heart genomic sequence, appears to be the product of alternative splicing from PFK‐2/FBPase‐2 gene B with an extended version of exon 15. Northern blot analysis indicated that this clone corresponds to an 8 kb mRNA expressed in multiple tissues, with the strongest signal in kidney, and detects several additional transcripts which may be alternatively spliced from gene B.
- University of Oxford United Kingdom
Mouse kidney, Phosphofructokinase-2, Phosphofructokinase-1, Molecular Sequence Data, Kidney, Polymerase Chain Reaction, Mice, 6Phosphofructo-2-kinase, Animals, Amino Acid Sequence, Cloning, Molecular, Gene Library, Base Sequence, Myocardium, Brain, Fructose-2,6-bisphosphatase, Exons, Blotting, Northern, Fructose-Bisphosphatase, Isoenzymes, Alternative Splicing, Fructose 2,6-bisphosphate, Liver, Organ Specificity, Glycolysis, Alternative splicing
Mouse kidney, Phosphofructokinase-2, Phosphofructokinase-1, Molecular Sequence Data, Kidney, Polymerase Chain Reaction, Mice, 6Phosphofructo-2-kinase, Animals, Amino Acid Sequence, Cloning, Molecular, Gene Library, Base Sequence, Myocardium, Brain, Fructose-2,6-bisphosphatase, Exons, Blotting, Northern, Fructose-Bisphosphatase, Isoenzymes, Alternative Splicing, Fructose 2,6-bisphosphate, Liver, Organ Specificity, Glycolysis, Alternative splicing
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