Ceftazidime-Avibactam Resistance Mediated by the N 346 Y Substitution in Various AmpC β-Lactamases
Copyright policy )Ceftazidime-Avibactam Resistance Mediated by the N 346 Y Substitution in Various AmpC β-Lactamases
Chromosomal and plasmid-borne AmpC cephalosporinases are a major resistance mechanism to β-lactams in Enterobacteriaceae and Pseudomonas aeruginosa . The new β-lactamase inhibitor avibactam effectively inhibits class C enzymes and can fully restore ceftazidime susceptibility. The conserved amino acid residue Asn 346 of AmpC cephalosporinases directly interacts with the avibactam sulfonate. Disruption of this interaction caused by the N 346 Y amino acid substitution in Citrobacter freundii AmpC was previously shown to confer resistance to the ceftazidime-avibactam combination (CAZ-AVI).
Drug Combinations, Bacterial Proteins, Microbial Sensitivity Tests, Azabicyclo Compounds, Ceftazidime, beta-Lactamases, Anti-Bacterial Agents
Drug Combinations, Bacterial Proteins, Microbial Sensitivity Tests, Azabicyclo Compounds, Ceftazidime, beta-Lactamases, Anti-Bacterial Agents
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