MicroRNA-155–deficient dendritic cells cause less severe GVHD through reduced migration and defective inflammasome activation
Copyright policy )MicroRNA-155–deficient dendritic cells cause less severe GVHD through reduced migration and defective inflammasome activation
Key PointsGVHD induction is dependent on functional miR-155 in DCs of the allo-HCT recipient. MiR-155 deficiency reduces ATP-mediated cell migration, ERK and inflammasome activation, and IL-1β production of DCs.
- University of Freiburg Germany
- University Medical Center Freiburg Germany
Male, Mice, Knockout, Mice, Inbred BALB C, Inflammasomes, Hematopoietic Stem Cell Transplantation, Graft vs Host Disease, Dendritic Cells, Severity of Illness Index, Mice, Inbred C57BL, Mice, MicroRNAs, Cell Movement, Animals, Transplantation, Homologous, Female, Cells, Cultured
Male, Mice, Knockout, Mice, Inbred BALB C, Inflammasomes, Hematopoietic Stem Cell Transplantation, Graft vs Host Disease, Dendritic Cells, Severity of Illness Index, Mice, Inbred C57BL, Mice, MicroRNAs, Cell Movement, Animals, Transplantation, Homologous, Female, Cells, Cultured
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