giant nucleiis essential in the cell cycle transition from meiosis to mitosis
Copyright policy )giant nucleiis essential in the cell cycle transition from meiosis to mitosis
At the transition from meiosis to cleavage mitoses, Drosophilarequires the cell cycle regulators encoded by the genes, giant nuclei(gnu), plutonium (plu) and pan gu(png). Embryos lacking Gnu protein undergo DNA replication and centrosome proliferation without chromosome condensation or mitotic segregation. We have identified the gnu gene encoding a novel phosphoprotein dephosphorylated by Protein phosphatase 1 at egg activation. Gnu is normally expressed in the nurse cells and oocyte of the ovary and is degraded during the embryonic cleavage mitoses. Ovarian death and sterility result from gnu gain of function. gnu function requires the activity of pan gu and plu.
- New York University United States
- University of Oxford United Kingdom
- University of Cambridge United Kingdom
- The Open University United Kingdom
- California Institute of Technology United States
DNA Replication, Male, 570, Molecular Sequence Data, Mitosis, Cell Cycle Proteins, DNA replication, Oogenesis, Protein phosphatase 1, Animals, Drosophila Proteins, Amino Acid Sequence, Cell Nucleus, Base Sequence, Ovary, Gene Expression Regulation, Developmental, Epistasis, Genetic, Actins, DNA-Binding Proteins, Meiosis, Drosophila melanogaster, Fertilization, Infertility, Oocytes, Female
DNA Replication, Male, 570, Molecular Sequence Data, Mitosis, Cell Cycle Proteins, DNA replication, Oogenesis, Protein phosphatase 1, Animals, Drosophila Proteins, Amino Acid Sequence, Cell Nucleus, Base Sequence, Ovary, Gene Expression Regulation, Developmental, Epistasis, Genetic, Actins, DNA-Binding Proteins, Meiosis, Drosophila melanogaster, Fertilization, Infertility, Oocytes, Female
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