Association analysis of the 5-HT6 receptor polymorphism C267T in Alzheimer's disease
Copyright policy ) S J, Tsai; H C, Liu; T Y, Liu; Y C, Wang; C J, Hong;
Association analysis of the 5-HT6 receptor polymorphism C267T in Alzheimer's disease
Serotonergic dysfunction has been implicated in the pathogenesis of Alzheimer's disease (AD). This association study explores whether the serotonin 6 receptor (5-HT6) polymorphism (C267T) is a susceptibility factor for AD. Statistical analysis showed a significant difference in the genotype and gene frequencies between the AD group and the normal controls (P = 0.006; and P = 0.023, respectively). These findings indicate that the 267C allele of the 5-HT6 gene is a risk factor for AD.
- National Yang Ming University Taiwan
- National Chiao Tung University Taiwan
Aged, 80 and over, Male, Polymorphism, Genetic, Genotype, Alzheimer Disease, Receptors, Serotonin, Humans, Female, Alleles, Aged
Aged, 80 and over, Male, Polymorphism, Genetic, Genotype, Alzheimer Disease, Receptors, Serotonin, Humans, Female, Alleles, Aged
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citations
Citations provided by BIP!
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citations provided by BIP!popularityPopularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Popularity provided by BIP! 50
Top 10%
Top 10%
Top 10%
