Frequency of HLA class 1 and 2 alleles in Brazilian patients with AIDS and cytomegalovirus retinitis
Copyright policy )Frequency of HLA class 1 and 2 alleles in Brazilian patients with AIDS and cytomegalovirus retinitis
Abstract.Purpose: To evaluate the human leucocyte antigen (HLA) class 1 (HLA‐A and HLA‐B) and HLA class 2 (HLA‐DRB1 and HLA‐DQB1) allele profiles in the susceptibility to cytomegalovirus retinitis (CMV‐R) in patients with AIDS. Methods: Cytomegalovirus retinitis was clinically diagnosed by indirect binocular ophthalmoscopy. Human leucocyte antigens class 1 were typed using a complement‐dependent microlymphocytotoxicity assay, and HLA class 2 alleles were identified using amplified DNA hybridized to sequence‐specific oligonucleotide primers. Results: The frequencies of HLA class 1 antigens and HLA class 2 alleles observed in patients and controls were similar; however, HLA‐A31 antigen was over‐represented in patients with AIDS, independent of the presence of CMV‐R. Conclusion: There was no association between HLA molecules/alleles and CMV‐R in Brazilian patients with AIDS. However, the results support the role of the HLA system in the susceptibility to developing AIDS.
- UNIVERSIDADE DE SAO PAULO Brazil
- Universidade de São Paulo Brazil
Adult, Male, Acquired Immunodeficiency Syndrome, Adolescent, HLA-A Antigens, Histocompatibility Antigens Class I, Histocompatibility Antigens Class II, Infant, Middle Aged, Gene Frequency, Child, Preschool, Cytomegalovirus Retinitis, Humans, Female, Genetic Predisposition to Disease, Child, Alleles, Brazil, Aged
Adult, Male, Acquired Immunodeficiency Syndrome, Adolescent, HLA-A Antigens, Histocompatibility Antigens Class I, Histocompatibility Antigens Class II, Infant, Middle Aged, Gene Frequency, Child, Preschool, Cytomegalovirus Retinitis, Humans, Female, Genetic Predisposition to Disease, Child, Alleles, Brazil, Aged
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