Dissociations within short-term memory in GluA1 AMPA receptor subunit knockout mice
Copyright policy )Dissociations within short-term memory in GluA1 AMPA receptor subunit knockout mice
GluA1 AMPA receptor subunit knockout mice display a selective impairment on short-term recognition memory tasks. In this study we tested whether GluA1 is important for short-term memory that is necessary for bridging the discontiguity between cues in trace conditioning. GluA1 knockout mice were not impaired at using short-term memory traces of T-maze floor inserts, made of different materials, to bridge the temporal gap between conditioned stimuli and reinforcement during appetitive discrimination tasks. Thus, different aspects of short-term memory are differentially sensitive to GluA1 deletion. This dissociation may reflect processing of qualitatively different short-term memory traces. Memory that results in performance of short-term recognition (e.g. for objects or places) may be different from the memory required for associative learning in trace conditioning.
- University of Oxford United Kingdom
- Max Planck Society Germany
- Max Planck Institute for Medical Research Germany
- Department of Experimental Psychology University of Oxford United Kingdom
- Durham University United Kingdom
Research Report, Trace conditioning, Non-spatial memory, Behavioral Neuroscience, Mice, Spatial memory, Spatial memory., Discrimination, Psychological, Conditioning, Psychological, Animals, Receptors, AMPA, AMPA receptors, Maze Learning, Mice, Knockout, Memory Disorders, Conditional learning, Association Learning, Disease Models, Animal, Memory, Short-Term, Space Perception, Female, Cues
Research Report, Trace conditioning, Non-spatial memory, Behavioral Neuroscience, Mice, Spatial memory, Spatial memory., Discrimination, Psychological, Conditioning, Psychological, Animals, Receptors, AMPA, AMPA receptors, Maze Learning, Mice, Knockout, Memory Disorders, Conditional learning, Association Learning, Disease Models, Animal, Memory, Short-Term, Space Perception, Female, Cues
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