Upregulation of long noncoding RNA AP003419.16 predicts high risk of aging-associated idiopathic pulmonary fibrosis
Copyright policy )Upregulation of long noncoding RNA AP003419.16 predicts high risk of aging-associated idiopathic pulmonary fibrosis
Long noncoding RNAs (lncRNAs) are able to regulate adjacent genes and thus participate in the incidence in the present study has identified lncRNA AP003419.16, adjacent to the protein‑coding gene ribosomal protein S6 kinase B‑2 (RPS6KB2). RPS6KB2 is believed to be involved in the process of aging and idiopathic pulmonary fibrosis (IPF), due to its activation by growth factors and regulation by the protein kinase mTOR signaling pathway. The results of the present study indicated that the expression of AP003419.16 increased significantly in patients with IPF, whereas its adjacent gene ribosomal protein S6 kinase B‑2 increased simultaneously. AP003419.16 expression may be used to predict an increased risk of aging‑associated IPF. The present study provided a molecular hypothesis of IPF occurrence in the aging process, in addition to novel molecular targets for the clinical treatment of IPF.
- Shanxi Medical University China (People's Republic of)
- First Hospital of Shanxi Medical University China (People's Republic of)
TOR Serine-Threonine Kinases, Age Factors, Computational Biology, Reproducibility of Results, Ribosomal Protein S6 Kinases, 70-kDa, Articles, Idiopathic Pulmonary Fibrosis, Up-Regulation, Gene Expression Regulation, Humans, Genetic Predisposition to Disease, RNA Interference, RNA, Long Noncoding, RNA, Messenger, Signal Transduction
TOR Serine-Threonine Kinases, Age Factors, Computational Biology, Reproducibility of Results, Ribosomal Protein S6 Kinases, 70-kDa, Articles, Idiopathic Pulmonary Fibrosis, Up-Regulation, Gene Expression Regulation, Humans, Genetic Predisposition to Disease, RNA Interference, RNA, Long Noncoding, RNA, Messenger, Signal Transduction
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).20 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!