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Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Dec 2011Embargo end date: 01 Jan 2011 Switzerland English Publisher:Oxford University Press (OUP)Journal:Genetics, volume 189, pages 1,177-1,201 (eissn: 1943-2631,

Copyright policy )Funded by:SNSF | Growth control by TOR sig..., UKRI | Field Enhanced Sintering ..., SNSF | TOR signaling and control... +1 projects

Authors: Loewith, R.; Hall, M. N.;

doi: 10.1534/genetics.111.133363 , 10.5167/uzh-78930

pmid: 22174183

pmc: PMC3241408

Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control

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Abstract

Abstract TOR (Target Of Rapamycin) is a highly conserved protein kinase that is important in both fundamental and clinical biology. In fundamental biology, TOR is a nutrient-sensitive, central controller of cell growth and aging. In clinical biology, TOR is implicated in many diseases and is the target of the drug rapamycin used in three different therapeutic areas. The yeast Saccharomyces cerevisiae has played a prominent role in both the discovery of TOR and the elucidation of its function. Here we review the TOR signaling network in S. cerevisiae.

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Switzerland

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570, Saccharomyces cerevisiae Proteins, SX20 Research, Technology and Development Projects, YeastBook, Saccharomyces cerevisiae, SX00 SystemsX.ch, 1311 Genetics, 570 Life sciences; biology, SX16 YeastX, Signal Transduction, ddc: ddc:570

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	759
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 0.1%
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