General Nature of the STAT3-Activated Anti-Inflammatory Response
Copyright policy )General Nature of the STAT3-Activated Anti-Inflammatory Response
Abstract Although many cytokine receptors generate their signals via the STAT3 pathway, the IL-10R appears unique in promoting a potent anti-inflammatory response (AIR) via STAT3 to antagonize proinflammatory signals that activate the innate immune response. We found that heterologous cytokine receptor systems that activate STAT3 but are naturally refractory (the IL-22R), or engineered to be refractory (the IL-6, leptin, and erythropoietin receptors), to suppressor of cytokine signaling-3-mediated inhibition activate an AIR indistinguishable from IL-10. We conclude that the AIR is a generic cytokine signaling pathway dependent on STAT3 but not unique to the IL-10R.
- Walter and Eliza Hall Institute of Medical Research Australia
- University of Michigan–Flint United States
- United States Food and Drug Administration United States
- Kanazawa University Japan
- Center for Drug Evaluation and Research United States
Inflammation, STAT3 Transcription Factor, Interleukin-6, Reverse Transcriptase Polymerase Chain Reaction, Immunoblotting, Gene Expression, Enzyme-Linked Immunosorbent Assay, Suppressor of Cytokine Signaling Proteins, Interleukin-10, Mice, Suppressor of Cytokine Signaling 3 Protein, Animals, Receptors, Interleukin-10, Oligonucleotide Array Sequence Analysis, Signal Transduction
Inflammation, STAT3 Transcription Factor, Interleukin-6, Reverse Transcriptase Polymerase Chain Reaction, Immunoblotting, Gene Expression, Enzyme-Linked Immunosorbent Assay, Suppressor of Cytokine Signaling Proteins, Interleukin-10, Mice, Suppressor of Cytokine Signaling 3 Protein, Animals, Receptors, Interleukin-10, Oligonucleotide Array Sequence Analysis, Signal Transduction
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