Eradicating acute myeloid leukemia in a MllPTD/wt:Flt3ITD/wt murine model: a path to novel therapeutic approaches for human disease
Copyright policy )Eradicating acute myeloid leukemia in a MllPTD/wt:Flt3ITD/wt murine model: a path to novel therapeutic approaches for human disease
Key PointsThe MllPTD/wt:Flt3ITD/wt mouse is a relevant AML model in which the miR-29b–mediated epigenetics-kinome crosstalk is targetable by bortezomib. An original liposomal formulation of bortezomib eradicates AML and yields curative therapy for MllPTD/wt:Flt3ITD/wt AML.
- University of Minnesota System United States
- University of Minnesota Morris United States
- University of Minnesota United States
- Nationwide Children's Hospital United States
- James Cancer Hospital United States
Drug Carriers, Leukemia, Experimental, Antineoplastic Agents, Histone-Lysine N-Methyltransferase, DNA Methylation, Boronic Acids, Mice, Mutant Strains, Bortezomib, Leukemia, Myeloid, Acute, Mice, MicroRNAs, Tandem Repeat Sequences, Pyrazines, Liposomes, Mutation, Animals, Humans, RNA, Neoplasm, Proteasome Inhibitors, Myeloid-Lymphoid Leukemia Protein
Drug Carriers, Leukemia, Experimental, Antineoplastic Agents, Histone-Lysine N-Methyltransferase, DNA Methylation, Boronic Acids, Mice, Mutant Strains, Bortezomib, Leukemia, Myeloid, Acute, Mice, MicroRNAs, Tandem Repeat Sequences, Pyrazines, Liposomes, Mutation, Animals, Humans, RNA, Neoplasm, Proteasome Inhibitors, Myeloid-Lymphoid Leukemia Protein
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