The Wingless target gene Dfz3 encodes a new member of the Drosophila Frizzled family
Copyright policy )The Wingless target gene Dfz3 encodes a new member of the Drosophila Frizzled family
Here we report the identification of Dfz3, a novel member of the Frizzled family of seven-pass transmembrane receptors. Like Dfz2, Dfz3 is a target gene of Wingless (Wg) signalling, but in contrast to Dfz2, it is activated rather than repressed by Wg signalling in imaginal discs. We show that Dfz3 is not required for viability but is necessary for optimal Wg signalling at the wing margin.
- Spanish National Research Council Spain
- University of Zurich Switzerland
Embryology, Molecular Sequence Data, Genes, Insect, Receptors, Cell Surface, 2710 Embryology, Wnt1 Protein, 10124 Institute of Molecular Life Sciences, Frizzled Receptors, Receptors, G-Protein-Coupled, 1309 Developmental Biology, Proto-Oncogene Proteins, 570 Life sciences; biology, Animals, Drosophila Proteins, Insect Proteins, Drosophila, Amino Acid Sequence, Developmental Biology
Embryology, Molecular Sequence Data, Genes, Insect, Receptors, Cell Surface, 2710 Embryology, Wnt1 Protein, 10124 Institute of Molecular Life Sciences, Frizzled Receptors, Receptors, G-Protein-Coupled, 1309 Developmental Biology, Proto-Oncogene Proteins, 570 Life sciences; biology, Animals, Drosophila Proteins, Insect Proteins, Drosophila, Amino Acid Sequence, Developmental Biology
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