No association between transmembrane protein–tyrosine–phosphatase receptor type C (CD45) exon A 77C>G transversion and Hashimoto's thyroiditis in a German population
Copyright policy )No association between transmembrane protein–tyrosine–phosphatase receptor type C (CD45) exon A 77C>G transversion and Hashimoto's thyroiditis in a German population
The CD45 77C>G transversion (rs17612648) in exon A of the CD45 gene has been reported to be associated with the development of various autoimmune diseases. Because Hashimoto's thyroiditis (HT) is a typical autoimmune disease, we performed a study to determine the association of the 77C>G transversion with susceptibility to HT. We enrolled 170 patients and 230 healthy individuals in the study. The 77C>G transversion was genotyped by polymerase chain reaction-allele specific restriction enzyme analysis (PCR-ASRA). We found four patients and six control individuals who carried the 77C>G transversion in a heterozygous form. No homozygous individual was detected in patients with HT or control population. The frequency of the 77G allele in patients was 1.2%, which did not significantly differ from 1.3% in controls (p = 0.871). Our data did not reveal any association between CD45 77C>G transversion and susceptibility to HT in a German population.
- Universität Hamburg Germany
- Jena University Hospital Germany
Adult, Aged, 80 and over, Male, Adolescent, Genotype, Exons, Hashimoto Disease, Middle Aged, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Young Adult, Gene Frequency, Germany, Humans, Leukocyte Common Antigens, Female, Genetic Predisposition to Disease, Child, Aged
Adult, Aged, 80 and over, Male, Adolescent, Genotype, Exons, Hashimoto Disease, Middle Aged, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Young Adult, Gene Frequency, Germany, Humans, Leukocyte Common Antigens, Female, Genetic Predisposition to Disease, Child, Aged
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