Cell surface expression of CD25 antigen (surface IL-2 receptor alpha-chain) is not a prognostic marker in chronic lymphocytic leukemia: results of a retrospective study of 281 patients
Copyright policy )Cell surface expression of CD25 antigen (surface IL-2 receptor alpha-chain) is not a prognostic marker in chronic lymphocytic leukemia: results of a retrospective study of 281 patients
Using the database of the Israeli CLL Study Group, we investigated the incidence and prognostic significance of CD25 expression on the surface of lymphocytic leukemia cells. Strong CD25 expression was found in 46 (16.4 %) of 281 tested cases and was correlated with the presence of splenomegaly (p = 0.04), expression of CD38 antigen (p = 0.001), and FMC-7 (p = 0.04). Age, gender, Binet stage, circulating lymphocyte count, presence of anemia or thrombocytopenia, atypical cell morphology, serum beta 2-microglobulin level, and ZAP-70 expression did not differ in patients with or without cell surface CD25. There was no correlation between CD25 expression and time to first treatment or overall survival. CD25 expression does not appear to be a prognostic factor in CLL.
- Tel Aviv University Israel
- Technion – Israel Institute of Technology Israel
- Bnai Zion Medical Center Israel
- Assaf Harofeh Medical Center Israel
- Bar-Ilan University Israel
Adult, Aged, 80 and over, Male, Databases, Factual, Interleukin-2 Receptor alpha Subunit, Middle Aged, Prognosis, Leukemia, Lymphocytic, Chronic, B-Cell, Cohort Studies, Gene Expression Regulation, Neoplastic, Survival Rate, Antigens, Surface, Humans, Female, Biomarkers, Aged, Follow-Up Studies, Retrospective Studies
Adult, Aged, 80 and over, Male, Databases, Factual, Interleukin-2 Receptor alpha Subunit, Middle Aged, Prognosis, Leukemia, Lymphocytic, Chronic, B-Cell, Cohort Studies, Gene Expression Regulation, Neoplastic, Survival Rate, Antigens, Surface, Humans, Female, Biomarkers, Aged, Follow-Up Studies, Retrospective Studies
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