Molecular Mimicry of Human Cytokine and Cytokine Response Pathway Genes by KSHV
Copyright policy )Molecular Mimicry of Human Cytokine and Cytokine Response Pathway Genes by KSHV
Four virus proteins similar to two human macrophage inflammatory protein (MIP) chemokines, interleukin-6 (IL-6), and interferon regulatory factor (IRF) are encoded by the Kaposi's sarcoma-associated herpesvirus (KSHV) genome. vIL-6 was functional in B9 proliferation assays and primarily expressed in KSHV-infected hematopoietic cells rather than KS lesions. HIV-1 transmission studies showed that vMIP-I is similar to human MIP chemokines in its ability to inhibit replication of HIV-1 strains dependent on the CCR5 co-receptor. These viral genes may form part of the response to host defenses contributing to virus-induced neoplasia and may have relevance to KSHV and HIV-I interactions.
- Columbia University United States
- King’s University United States
- Institute of Cancer Research United Kingdom
Herpesvirus 4, Human, Lymphoma, B-Cell, Genes, Viral, Receptors, CCR5, Interleukin-6, Molecular Mimicry, Molecular Sequence Data, Gene Expression, Macrophage Inflammatory Proteins, Cell Line, Mice, Herpesvirus 8, Human, HIV-1, Animals, Humans, Amino Acid Sequence, Lymph Nodes, Receptors, Cytokine, Chemokine CCL4, Cell Division
Herpesvirus 4, Human, Lymphoma, B-Cell, Genes, Viral, Receptors, CCR5, Interleukin-6, Molecular Mimicry, Molecular Sequence Data, Gene Expression, Macrophage Inflammatory Proteins, Cell Line, Mice, Herpesvirus 8, Human, HIV-1, Animals, Humans, Amino Acid Sequence, Lymph Nodes, Receptors, Cytokine, Chemokine CCL4, Cell Division
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