Human leukocyte antigen‐DR15, low infant sibling exposure and multiple sclerosis: Gene–environment interaction
Copyright policy )Human leukocyte antigen‐DR15, low infant sibling exposure and multiple sclerosis: Gene–environment interaction
AbstractThe risk for development of multiple sclerosis has been associated with human leukocyte antigen‐DRB1*1501‐DQB1*0602 (HLA‐DR15) genotype, low infant sibling exposure, and high Epstein–Barr nuclear antigen IgG levels. In a population‐based case–control study (Tasmania, Australia), we found that the combined effect of HLA‐DR15 positivity and low infant sibling exposure on multiple sclerosis (odds ratio, 7.88; 95% confidence interval, 3.43–18.11) was 3.9‐fold greater than expected (test for interaction, p = 0.019) This interaction was observed irrespective of Epstein–Barr nuclear antigen IgG levels. This suggests that immune mechanisms involving HLA class II molecules are susceptible to modulation in early life. Ann Neurol 2009;66:261–265 ANN NEUROL 2010;67:259–263
- Menzies Research Institute Australia
- University of Tasmania Australia
- Menzies Institute for Medical Research Australia
- Royal Children's Hospital Australia
- Children's Hospital at Westmead Australia
Adult, Male, Multiple Sclerosis, Genotype, Siblings, Infant, HLA-DR Antigens, Environment, Middle Aged, Epstein-Barr Virus Nuclear Antigens, Gene Frequency, Risk Factors, Case-Control Studies, Odds Ratio, Humans, Female, Genetic Predisposition to Disease, HLA-DR Serological Subtypes, Retrospective Studies
Adult, Male, Multiple Sclerosis, Genotype, Siblings, Infant, HLA-DR Antigens, Environment, Middle Aged, Epstein-Barr Virus Nuclear Antigens, Gene Frequency, Risk Factors, Case-Control Studies, Odds Ratio, Humans, Female, Genetic Predisposition to Disease, HLA-DR Serological Subtypes, Retrospective Studies
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