We report the novel HLA‐Cw allele HLA‐Cw*0751. The allele was identified during routine sequence‐based typing in our laboratory. The novel allele is identical to Cw*07020101 except for a single nucleotide change in codon 90.2 in position 268. HLA‐Cw*0751 allele possesses an adenine at position 268 in exon 2, while HLA‐Cw*07020101 has a cytosine at this position. Although this substitution does not change serologic reactivity of HLA‐Cw7 molecule, it changes the amino acid at codon 90 from an aspartic acid to an alanine. Aspartic acid is polar and acidic, while alanine is non‐polar and neutral.