Assignment of the erythropoietin receptor (EPOR) gene to mouse chromosome 9 and human chromosome 19
Copyright policy )Assignment of the erythropoietin receptor (EPOR) gene to mouse chromosome 9 and human chromosome 19
Erythropoietin (EPO), the primary regulator of mammalian erythropoiesis, binds and activates a specific receptor on erythroid progenitors. The human and mouse cDNAs for this receptor (EPOR) have recently been isolated. These cDNAs were used to establish the genomic location of the EPOR gene. By somatic cell hybrid analysis, the locus for the EPOR maps to human chromosome (Chr) 19pter-q12. By interspecific backcross mapping the locus is tightly linked to the murine Ldlr locus near the centromere of mouse Chr9. This region of mouse Chr9 is homologous to a region of human Chr 19p13 carrying the human LDLR and MEL loci, strongly suggesting that the human EPOR gene is at 19p13 near the human LDLR locus.
- Harvard University United States
- Dana-Farber Cancer Institute United States
- Children's Hospital of Philadelphia United States
- Temple University United States
- University of Pennsylvania United States
Genetic Markers, Genetic Linkage, Chromosome Mapping, Receptors, Cell Surface, Hybrid Cells, Mice, Inbred C57BL, Muridae, Mice, Genes, Species Specificity, Receptors, Erythropoietin, Animals, Humans, Chromosomes, Human, Pair 19, Crosses, Genetic
Genetic Markers, Genetic Linkage, Chromosome Mapping, Receptors, Cell Surface, Hybrid Cells, Mice, Inbred C57BL, Muridae, Mice, Genes, Species Specificity, Receptors, Erythropoietin, Animals, Humans, Chromosomes, Human, Pair 19, Crosses, Genetic
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