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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
https://doi.org/10.1007/978-94...
Part of book or chapter of book . 2001 . Peer-reviewed
License: Springer TDM
Data sources: Crossref
https://dx.doi.org/10.1007/978...
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Highly Potent Analogs of Human Parathyroid Hormone and Human Parathyroid Hormone-Related Protein

descriptionPublicationkeyboard_double_arrow_right Part of book or chapter of book , Other literature type 01 Jan 2001 English Publisher:Springer Netherlands
Authors: Jesse Z. Dong; Yeelana Shen; Michael Culler; John E. Taylor; Chee-Wai Woon; Jean-Jacques Legrand; Barry Morgan; +4 Authors

doi: 10.1007/978-94-010-0464-0_311

Highly Potent Analogs of Human Parathyroid Hormone and Human Parathyroid Hormone-Related Protein

Abstract

It is well established that intermittently administered human parathyroid hormone, hPTH(1–84), and its fragment hPTH(1–34) effectively increase bone mass in animals and humans. Because of its unique bone anabolic effect, PTH is considered a potential therapeutic agent for the treatment of osteoporosis. However, the native hPTH(l-84) and its fragment hPTH(l-34) have a relatively narrow therapeutic index, above which they can cause bone resorption and hypercalcemia. To address this problem, we have designed and identified novel PTH/PTHrP analogs that have a wider therapeutic index.

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
4
Average
Average
Average
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