Quaternary Ammonium Salts Based on (-)-Borneol as Effective Inhibitors of Influenza Virus
Copyright policy )Quaternary Ammonium Salts Based on (-)-Borneol as Effective Inhibitors of Influenza Virus
Abstract A new compounds containing 1,7,7-trimethylbicyclo[2.2.1]heptane fragment has been found to exhibit potent inhibitory activity against the influenza A(H1N1) virus. The most potent antiviral compound 10a is a quaternary ammonium salt based on (-)-borneol, with a therapeutic index of more than 500. Mechanism-of-action studies for compound 10a were performed. The compound appeared the most effective when added at the early stages of viral life cycle. In direct hemagglutinin inhibition tests the agent, 10a, was shown to decrease the activity of hemagglutinin of influenza virus A/Puerto Rico/8/34. According to the results of molecular modelling, the lead-compound, 10a, can attach at the binding sites of the stem part of the HA. These results prove that monoterpenoids with 1,7,7-trimethylbicyclo[2.2.1]heptane fragment are prospective natural compounds for the development of antiviral agents.
- St Petersburg University Russian Federation
- Novosibirsk Institute of Organic Chemistry Russian Federation
- Institut Pasteur France
- Ufa Institute of Chemistry Russian Federation
- Russian Academy of Sciences Russian Federation
Camphanes, Hemagglutinin Glycoproteins, Influenza Virus, Antiviral Agents, Cell Line, Madin Darby Canine Kidney Cells, Quaternary Ammonium Compounds, Dogs, Influenza A Virus, H1N1 Subtype, Orthomyxoviridae Infections, Alkanes, Ammonium Compounds, Animals, Original Article, Salts
Camphanes, Hemagglutinin Glycoproteins, Influenza Virus, Antiviral Agents, Cell Line, Madin Darby Canine Kidney Cells, Quaternary Ammonium Compounds, Dogs, Influenza A Virus, H1N1 Subtype, Orthomyxoviridae Infections, Alkanes, Ammonium Compounds, Animals, Original Article, Salts
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