Cloning and characterization of the mouse gene encoding mammary-derived growth inhibitor/heart-fatty acid-binding protein
Copyright policy )Cloning and characterization of the mouse gene encoding mammary-derived growth inhibitor/heart-fatty acid-binding protein
From a mouse genomic library we isolated and characterized a gene, Fabph1, encoding mammary-derived growth inhibitor (MDGI)/heart fatty-acid-binding protein (H-FABP). Exon sequences were identical with a MDGI-encoding cDNA isolated previously from the mammary gland of pregnant mice. The product of this gene has also been detected in heart, where it had been termed H-FABP. It has an intron/exon structure similar to other FABP-encoding genes. In addition to this expressed gene, we isolated a related intronless pseudogene, Fabph-ps, with an open reading frame which was highly conserved when compared with Fabph1. Fabph1 was positioned on chromosome (Chr) 4 using interrelated sequence locus, Fabph-rs1, to Chr 8. A Mus spretus-specific related sequence, Fabph-rs2, was identified on Chr 17 by analysis of interspecies crosses. The 5'-flanking region of Fabph1 contains putative transcription factor-binding elements which could account for its constitutive expression in muscle tissue, as well as for its developmental stage-dependent expression in mammary epithelium.
- National Cancer Institute United States
- National Institute of Health Pakistan
- Max Delbrück Center for Molecular Medicine Germany
- Helmholtz Association of German Research Centres Germany
- University of Bergen Norway
DNA, Complementary, Base Sequence, Myocardium, Fatty Acids, Molecular Sequence Data, Nerve Tissue Proteins, Hybrid Cells, Fatty Acid-Binding Proteins, Growth Inhibitors, Neoplasm Proteins, Mice, Cricetinae, Animals, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular, Carrier Proteins, Fatty Acid-Binding Protein 7, Peptides, Fatty Acid Binding Protein 3
DNA, Complementary, Base Sequence, Myocardium, Fatty Acids, Molecular Sequence Data, Nerve Tissue Proteins, Hybrid Cells, Fatty Acid-Binding Proteins, Growth Inhibitors, Neoplasm Proteins, Mice, Cricetinae, Animals, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular, Carrier Proteins, Fatty Acid-Binding Protein 7, Peptides, Fatty Acid Binding Protein 3
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