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Notch Signaling: Piercing a Harness of Simplicity

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Nov 2015 English Publisher:Elsevier BVJournal:Immunity, volume 43, pages 831-833 (issn: 1074-7613, Copyright policy )
Authors: Helbig, Christina; Amsen, Derk;

doi: 10.1016/j.immuni.2015.10.022

pmid: 26588772

Notch Signaling: Piercing a Harness of Simplicity

Abstract

The Notch pathway is an attractive therapeutic target for treatment of cancer and T cell-mediated pathology, but Notch inhibition leads to many side effects. Pinnell et al. (2015) demonstrate that oncogenic functions can be separated biochemically from other functions of Notch, opening new options for more selective targeting of this pathway.

Related Organizations
Keywords

Infectious Diseases, Leukemia, T-Lymphocytes, Immunology, Immunology and Allergy, Animals, Humans, Receptor, Notch1, Protein Inhibitors of Activated STAT, Transcription Factors

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    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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    influence
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
5
Average
Average
Average
hybrid
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