Ethnic variation in CYP2A6*7, CYP2A6*8 and CYP2A6*10 as assessed with a novel haplotyping method
Copyright policy )Ethnic variation in CYP2A6*7, CYP2A6*8 and CYP2A6*10 as assessed with a novel haplotyping method
Cytochrome P450 2A6 is the main human nicotine metabolizing enzyme coded for by a highly polymorphic gene, CYP2A6. CYP2A6*7, CYP2A6*8 and CYP2A6*10 are variant alleles common to Asian ethnicities. The CYP2A6*7 and CYP2A6*8 alleles each contain a non-synonymous single nucleotide polymorphism (SNP) 6558T>C and 6600G>T, respectively, whereas the CYP2A6*10 haplotype allele contains both. We have developed the first haplotyping assay; it can unambiguously distinguish the CYP2A6*7, CYP2A6*8 and CYP2A6*10 alleles. The allele frequencies of these three variants were assessed using the novel haplotyping assay in Chinese-Canadian (n=112), Chinese-American (n=221), Taiwanese (n=319), Korean-American (n=207) and Japanese-Canadian (n=64) populations, as well as in Caucasian (n=110) and African-Canadian (n=113) populations. Our new method demonstrated higher frequencies of CYP2A6*7 and CYP2A6*10, and a lower frequency of CYP2A6*8 in Asian populations, but no significant change of allele frequencies in Caucasian or African-Canadian populations.
- University of Toronto Canada
- University of California, San Diego United States
- Bronx Veterans Medical Research Foundation United States
Canada, China, Korea, Genotype, Models, Genetic, Black People, Genetic Variation, Exons, Polymorphism, Single Nucleotide, Mixed Function Oxygenases, Cytochrome P-450 CYP2A6, Phenotype, Asian People, Gene Frequency, Haplotypes, Japan, Africa, Humans, Aryl Hydrocarbon Hydroxylases, Alleles
Canada, China, Korea, Genotype, Models, Genetic, Black People, Genetic Variation, Exons, Polymorphism, Single Nucleotide, Mixed Function Oxygenases, Cytochrome P-450 CYP2A6, Phenotype, Asian People, Gene Frequency, Haplotypes, Japan, Africa, Humans, Aryl Hydrocarbon Hydroxylases, Alleles
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