Gfi-1 regulates the erythroid transcription factor network through Id2 repression in murine hematopoietic progenitor cells
Copyright policy )Gfi-1 regulates the erythroid transcription factor network through Id2 repression in murine hematopoietic progenitor cells
Key Points Reducing Id2 in Gfi-1−/− mice restores radioprotective function of hematopoietic progenitors and partially rescues erythroid development. Rescue of erythroid development in Gfi-1−/− mice by Id2 reduction directly correlates with an increase of Gata1, Eklf, and EpoR expression.
- National Cancer Institute United States
- Frederick National Laboratory for Cancer Research United States
- Science Applications International Corporation (United States) United States
- Leidos Biomedical Research Inc. (United States) United States
Erythroid Precursor Cells, Mice, Knockout, Down-Regulation, Cell Differentiation, Hematopoietic Stem Cells, DNA-Binding Proteins, Mice, Inbred C57BL, Mice, Animals, Erythropoiesis, Gene Regulatory Networks, Cells, Cultured, Inhibitor of Differentiation Protein 2, Transcription Factors
Erythroid Precursor Cells, Mice, Knockout, Down-Regulation, Cell Differentiation, Hematopoietic Stem Cells, DNA-Binding Proteins, Mice, Inbred C57BL, Mice, Animals, Erythropoiesis, Gene Regulatory Networks, Cells, Cultured, Inhibitor of Differentiation Protein 2, Transcription Factors
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