Sry and the hesitant beginnings of male development
Copyright policy )Sry and the hesitant beginnings of male development
In mammals, Sry (sex-determining region Y gene) is the master regulator of male sex determination. The discovery of Sry in 1990 was expected to provide the key to unravelling the network of gene regulation underlying testis development. Intriguingly, no target gene of SRY protein has yet been discovered, and the mechanisms by which it mediates its developmental functions are still elusive. What is clear is that instead of the robust gene one might expect as the pillar of male sexual development, Sry function hangs by a thin thread, a situation that has profound biological, medical and evolutionary implications.
- University of Queensland Australia
- University of Queensland Australia
- University of Queensland Australia
- Terrestrial Ecosystem Research Network Australia
- THE UNIVERSITY OF QUEENSLAND Australia
Male, Mobility-group Domain, Sex Differentiation, Mouse Genital Ridge, Evolution, Molecular Sequence Data, sex determination, Determining Gene Sry, 590, 060403 Developmental Genetics (incl. Sex Determination), testis development, Sex-determining Gene, Molecular mechanism, C1, Sry, evolution, Animals, Humans, Hmg Box Region, Nuclear Import, Pre-sertoli Cells, Amino Acid Sequence, Genes, sry, Testis-determining Gene, Molecular Biology, 780105 Biological sciences, Campomelic Dysplasia, 270205 Genetic Development (incl. Sex Determination), High Mobility Group Proteins, Gene Expression Regulation, Developmental, SOX9 Transcription Factor, Cell Biology, brain gender, Sex determination, Sex Determination Processes, Xx Transgenic Mice, Sex-Determining Region Y Protein, Testis development, Organ Specificity, Female, molecular mechanism, Brain gender, Developmental Biology, Transcription Factors
Male, Mobility-group Domain, Sex Differentiation, Mouse Genital Ridge, Evolution, Molecular Sequence Data, sex determination, Determining Gene Sry, 590, 060403 Developmental Genetics (incl. Sex Determination), testis development, Sex-determining Gene, Molecular mechanism, C1, Sry, evolution, Animals, Humans, Hmg Box Region, Nuclear Import, Pre-sertoli Cells, Amino Acid Sequence, Genes, sry, Testis-determining Gene, Molecular Biology, 780105 Biological sciences, Campomelic Dysplasia, 270205 Genetic Development (incl. Sex Determination), High Mobility Group Proteins, Gene Expression Regulation, Developmental, SOX9 Transcription Factor, Cell Biology, brain gender, Sex determination, Sex Determination Processes, Xx Transgenic Mice, Sex-Determining Region Y Protein, Testis development, Organ Specificity, Female, molecular mechanism, Brain gender, Developmental Biology, Transcription Factors
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