Role of medial prefrontal cortex Narp in the extinction of morphine conditioned place preference
Copyright policy )Role of medial prefrontal cortex Narp in the extinction of morphine conditioned place preference
Narp knockout (KO) mice demonstrate an impaired extinction of morphine conditioned place preference (CPP). Because the medial prefrontal cortex (mPFC) has been implicated in extinction learning, we tested whether Narp cells in this region play a role in the extinction of morphine CPP. We found that intracranial injections of adenoassociated virus (AAV) expressing wild-type (WT) Narp into the mPFC of Narp KO mice rescued the extinction and the injection of AAV expressing a dominant negative form of Narp (NarpN) into the mPFC of WT mice impaired the extinction of morphine CPP. These findings suggest that Narp in the mPFC mediates the extinction of morphine CPP.
- Johns Hopkins University United States
- The Ohio State University United States
- JOHNS HOPKINS UNIVERSITY
- National Institute of Health Pakistan
- THE OHIO STATE UNIVERSITY United States
Male, Mice, Knockout, Narcotics, Analysis of Variance, Microinjections, Morphine, Prefrontal Cortex, Nerve Tissue Proteins, Dependovirus, Extinction, Psychological, Mice, Inbred C57BL, Luminescent Proteins, Mice, C-Reactive Protein, Bacterial Proteins, Animals, Conditioning, Operant
Male, Mice, Knockout, Narcotics, Analysis of Variance, Microinjections, Morphine, Prefrontal Cortex, Nerve Tissue Proteins, Dependovirus, Extinction, Psychological, Mice, Inbred C57BL, Luminescent Proteins, Mice, C-Reactive Protein, Bacterial Proteins, Animals, Conditioning, Operant
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