From ER to Eph Receptors: New Roles for VAP Fragments
Copyright policy )From ER to Eph Receptors: New Roles for VAP Fragments
Dominantly inherited mutations in an endoplasmic reticulum protein called VAPB have been found in a subset of patients with a rare familial form of amyotrophic lateral sclerosis (ALS). In this issue, Tsuda et al. (2008) identify a secreted form of VAPB that binds directly to Eph receptors inducing their activation and signaling, providing fresh insights into ALS pathogenesis, including non-neuronal aspects of this disorder.
- Jackson Laboratory United States
- Howard Hughes Medical Institute United States
Signal-Transduction, Receptors-Eph-Family, Biochemistry, Genetics and Molecular Biology(all), Amyotrophic Lateral Sclerosis, Vesicular Transport Proteins, 610, Animals, Humans, Vesicular-Transport-Proteins, Receptors, Eph Family, Signal Transduction
Signal-Transduction, Receptors-Eph-Family, Biochemistry, Genetics and Molecular Biology(all), Amyotrophic Lateral Sclerosis, Vesicular Transport Proteins, 610, Animals, Humans, Vesicular-Transport-Proteins, Receptors, Eph Family, Signal Transduction
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