Additional file 3: of The integrated stress response regulates BMP signalling through effects on translation
Additional file 3: of The integrated stress response regulates BMP signalling through effects on translation
Figure S3. crc regulates genes involved in translation including 4E-BP. (A, B) KEGG pathway analysis performed on microarray data HA-crcA.pMT-Puro S2 stable cells relative to HA.pMT-Puro S2 stable cells, each treated with 0.7 mM CuSO4 for 3 h or 6 h to identify pathways significantly enriched within the list of differentially expressed up- or down-regulated genes with fold change of at least 1.62. Similar analysis was performed on microarrays of dGCN2-CA-V5.pMT-Puro S2 stable cells at 12 h. (C) Venn diagram to illustrate â Translationâ Gene Ontology (GO) term genes induced by dGCN2, crc or both. (D) d4E-BP (Thor) mRNA level following expression of crc for the indicated times. (E) Immunoblot of cell lysates of cells expressing crc for the indicated times. (F) Effect of d4E-BP RNAi (16 h) on MAD phosphorylation over a range of dpp concentrations (1 h treatment). (PDF 2491 kb)
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