Interaction of drugs candidates with various SARS-CoV-2 receptors: an in silico study to combat COVID-19
Copyright policy )Interaction of drugs candidates with various SARS-CoV-2 receptors: an in silico study to combat COVID-19
The world is currently facing the COVID-19 pandemic caused by the SARS-CoV-2 virus. The pandemic is causing the death of people around the world and public and social health measures to slow or prevent the spread of COVID-19 are being implemented with the involvement of all members of society. Research institutions are accelerating the discovery of vaccines and therapies for the COVID-19. In this work, molecular docking was used to study (in silico) the interaction of twenty-four ligands, divided into four groups, with four important SARS-CoV-2 receptors. The results showed that Metaquine (group 01), antimalarial substance and the anti-HIV antiretroviral Saquinavir (group 03), presented interaction with all the studied receptors, indicating them as potentials candidates for muti-target drugs for COVID-19.
- International Federation of the Phonographic Industry United Kingdom
- Instituto Federal do Piauí Brazil
SARS-CoV-2, Pneumonia, Viral, COVID-19, General Chemistry, Biochemistry, Antiviral Agents, Molecular Docking Simulation, Betacoronavirus, Viral Proteins, Drug Discovery, Humans, Coronavirus Infections, Pandemics, Protein Binding
SARS-CoV-2, Pneumonia, Viral, COVID-19, General Chemistry, Biochemistry, Antiviral Agents, Molecular Docking Simulation, Betacoronavirus, Viral Proteins, Drug Discovery, Humans, Coronavirus Infections, Pandemics, Protein Binding
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