TGF-β signalling from cell membrane to nucleus through SMAD proteins
Copyright policy )TGF-β signalling from cell membrane to nucleus through SMAD proteins
The recent identification of the SMAD family of signal transducer proteins has unravelled the mechanisms by which transforming growth factor-beta (TGF-beta) signals from the cell membrane to the nucleus. Pathway-restricted SMADs are phosphorylated by specific cell-surface receptors that have serine/threonine kinase activity, then they oligomerize with the common mediator Smad4 and translocate to the nucleus where they direct transcription to effect the cell's response to TGF-beta. Inhibitory SMADs have been identified that block the activation of these pathway-restricted SMADs.
- Ludwig Institute for Cancer Research United States
- Ludwig Cancer Research Sweden
- Ludwig Cancer Research Belgium
Cell Nucleus, DNA-Binding Proteins, Cell Transformation, Neoplastic, Gene Expression Regulation, Transforming Growth Factor beta, Cell Membrane, Animals, Humans, Signal Transduction, Smad1 Protein
Cell Nucleus, DNA-Binding Proteins, Cell Transformation, Neoplastic, Gene Expression Regulation, Transforming Growth Factor beta, Cell Membrane, Animals, Humans, Signal Transduction, Smad1 Protein
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