A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors
Copyright policy )A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors
The COVID-19, caused by SARS-CoV-2, is threatening public health, and there is no effective treatment. In this study, we have implemented a multi-targeted anti-viral drug design strategy to discover highly potent SARS-CoV-2 inhibitors, which simultaneously act on the host ribosome, viral RNA as well as RNA-dependent RNA polymerases, and nucleocapsid protein of the virus, to impair viral translation, frameshifting, replication, and assembly. Driven by this strategy, three alkaloids, including lycorine, emetine, and cephaeline, were discovered to inhibit SARS-CoV-2 with EC50 values of low nanomolar levels potently. The findings in this work demonstrate the feasibility of this multi-targeting drug design strategy and provide a rationale for designing more potent anti-virus drugs.
- University of Chinese Academy of Sciences China (People's Republic of)
- Imperial College London United Kingdom
- Chinese Academy of Science (中国科学院) China (People's Republic of)
- Shanghai Institute of Materia Medica China (People's Republic of)
- Chinese Academy of Sciences China (People's Republic of)
Dose-Response Relationship, Drug, Molecular Structure, SARS-CoV-2, Microbial Sensitivity Tests, Antiviral Agents, Article, Cell Line, Structure-Activity Relationship, Drug Design, Chlorocebus aethiops, Animals, Humans
Dose-Response Relationship, Drug, Molecular Structure, SARS-CoV-2, Microbial Sensitivity Tests, Antiviral Agents, Article, Cell Line, Structure-Activity Relationship, Drug Design, Chlorocebus aethiops, Animals, Humans
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