Association of estrogen receptor-alpha gene polymorphisms with stroke risk in patients with metabolic syndrome
Copyright policy )Association of estrogen receptor-alpha gene polymorphisms with stroke risk in patients with metabolic syndrome
The vascular protective effects of estrogens are mediated by their binding to the two known estrogen receptors. In this study, we examine the association of stroke with two common polymorphisms of the ESR1 gene in patients with metabolic syndrome.DNA from 130 patients hospitalized for ischemic stroke and 240 healthy controls were genotyped for ESR1 PvuII and XbaI polymorphisms. Results - Comparing female and male patients, it was found that CCGG diplotype is more frequent in male patients (P = 0.03). In addition, the AA genotype is associated with the onset of stroke at a younger age in the male patient group (P < 0.05).These findings suggest that PvuII and XbaI polymorphisms may affect the age at onset of the first stroke and the probability of developing cerebrovascular disease.
- University of Ioannina Greece
Blood Glucose, Male, Genotype, Gene Expression, *Polymorphism, Genetic, Electrocardiography, Gene Frequency, Humans, Obesity, Age of Onset, Aged, Dyslipidemias, Metabolic Syndrome, Polymorphism, Genetic, Blood Glucose/metabolism, Metabolic Syndrome X/diagnosis/*epidemiology/metabolism, Stroke/diagnosis/*epidemiology/*genetics, Estrogen Receptor alpha, Brain, Middle Aged, Obesity/diagnosis/epidemiology, Dyslipidemias/diagnosis/epidemiology, Magnetic Resonance Imaging, Brain/pathology/radiography, Stroke, Hypertension, Estrogen Receptor alpha/*genetics, Female, Hypertension/diagnosis/epidemiology, Tomography, X-Ray Computed, Gene Expression/*genetics
Blood Glucose, Male, Genotype, Gene Expression, *Polymorphism, Genetic, Electrocardiography, Gene Frequency, Humans, Obesity, Age of Onset, Aged, Dyslipidemias, Metabolic Syndrome, Polymorphism, Genetic, Blood Glucose/metabolism, Metabolic Syndrome X/diagnosis/*epidemiology/metabolism, Stroke/diagnosis/*epidemiology/*genetics, Estrogen Receptor alpha, Brain, Middle Aged, Obesity/diagnosis/epidemiology, Dyslipidemias/diagnosis/epidemiology, Magnetic Resonance Imaging, Brain/pathology/radiography, Stroke, Hypertension, Estrogen Receptor alpha/*genetics, Female, Hypertension/diagnosis/epidemiology, Tomography, X-Ray Computed, Gene Expression/*genetics
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).22 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!