Acid sensing by the Drosophila olfactory system
Copyright policy )Acid sensing by the Drosophila olfactory system
The odour of acids has a distinct quality that is perceived as sharp, pungent and often irritating. How acidity is sensed and translated into an appropriate behavioural response is poorly understood. Here we describe a functionally segregated population of olfactory sensory neurons in the fruitfly, Drosophila melanogaster, that are highly selective for acidity. These olfactory sensory neurons express IR64a, a member of the recently identified ionotropic receptor (IR) family of putative olfactory receptors. In vivo calcium imaging showed that IR64a+ neurons projecting to the DC4 glomerulus in the antennal lobe are specifically activated by acids. Flies in which the function of IR64a+ neurons or the IR64a gene is disrupted had defects in acid-evoked physiological and behavioural responses, but their responses to non-acidic odorants remained unaffected. Furthermore, artificial stimulation of IR64a+ neurons elicited avoidance responses. Taken together, these results identify cellular and molecular substrates for acid detection in the Drosophila olfactory system and support a labelled-line mode of acidity coding at the periphery.
- University of Applied Sciences and Arts Western Switzerland Switzerland
- New York University United States
- Paris Diderot University France
- National Research Institute for Agriculture, Food and Environment France
- University of Burgundy France
Arthropod Antennae, 570, GENETICS, Sensory Receptor Cells, Ionotropic Glutamate, MESH: Drosophila Proteins, Acetic Acid/analysis; Acetic Acid/pharmacology; Acids/analysis; Acids/pharmacology; Animals; Arthropod Antennae/anatomy & histology; Arthropod Antennae/cytology; Calcium Signaling/drug effects; Carbon Dioxide/metabolism; Carbonic Acid/metabolism; Carbonic Acid/pharmacology; Drosophila Proteins/metabolism; Drosophila melanogaster/anatomy & histology; Drosophila melanogaster/cytology; Maze Learning; Odors/analysis; Olfactory Pathways/cytology; Olfactory Pathways/drug effects; Receptors, Ionotropic Glutamate/metabolism; Receptors, Odorant/metabolism; Sensilla/cytology; Sensory Receptor Cells/drug effects; Sensory Receptor Cells/metabolism; Temperature, MESH: Calcium Signaling, MESH: Carbon Dioxide, Receptors, Ionotropic Glutamate, Receptors, Odorant, MESH: Acids, MESH: Drosophila melanogaster, MESH: Sensory Receptor Cells, MESH: Receptors, Animals, Drosophila Proteins, MESH: Animals, Calcium Signaling, Sensilla, Maze Learning, Acetic Acid, MESH: Odors, MESH: Arthropod Antennae, MESH: Maze Learning, Temperature, Olfactory Pathways, Carbon Dioxide, MESH: Carbonic Acid, MESH: Sensilla, ANIMAL BEHAVIOUR, MESH: Temperature, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, Odorant, Drosophila melanogaster, NEUROSCIENCE, MESH: Acetic Acid, Carbonic Acid, Odorants, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, GENOMICS, Acids, MESH: Olfactory Pathways
Arthropod Antennae, 570, GENETICS, Sensory Receptor Cells, Ionotropic Glutamate, MESH: Drosophila Proteins, Acetic Acid/analysis; Acetic Acid/pharmacology; Acids/analysis; Acids/pharmacology; Animals; Arthropod Antennae/anatomy & histology; Arthropod Antennae/cytology; Calcium Signaling/drug effects; Carbon Dioxide/metabolism; Carbonic Acid/metabolism; Carbonic Acid/pharmacology; Drosophila Proteins/metabolism; Drosophila melanogaster/anatomy & histology; Drosophila melanogaster/cytology; Maze Learning; Odors/analysis; Olfactory Pathways/cytology; Olfactory Pathways/drug effects; Receptors, Ionotropic Glutamate/metabolism; Receptors, Odorant/metabolism; Sensilla/cytology; Sensory Receptor Cells/drug effects; Sensory Receptor Cells/metabolism; Temperature, MESH: Calcium Signaling, MESH: Carbon Dioxide, Receptors, Ionotropic Glutamate, Receptors, Odorant, MESH: Acids, MESH: Drosophila melanogaster, MESH: Sensory Receptor Cells, MESH: Receptors, Animals, Drosophila Proteins, MESH: Animals, Calcium Signaling, Sensilla, Maze Learning, Acetic Acid, MESH: Odors, MESH: Arthropod Antennae, MESH: Maze Learning, Temperature, Olfactory Pathways, Carbon Dioxide, MESH: Carbonic Acid, MESH: Sensilla, ANIMAL BEHAVIOUR, MESH: Temperature, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, Odorant, Drosophila melanogaster, NEUROSCIENCE, MESH: Acetic Acid, Carbonic Acid, Odorants, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, GENOMICS, Acids, MESH: Olfactory Pathways
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