Variations in DNA topoisomerase I activity after gamma irradiation of mature neurons
Copyright policy )Variations in DNA topoisomerase I activity after gamma irradiation of mature neurons
The activity of DNA topoisomerase I in nuclear extracts from rat cerebral cortex neurons increases about two-fold after gamma irradiation (700 rads) of rats or incubated cerebral cortex slices. Analysis of the salt dependence of the DNA topoisomerase I association with chromatin shows a change of the activity only for tight-bound pool of the enzyme. The change appears to reflect a modification of the enzyme which results from its repair function.
- Russian Academy of Sciences Russian Federation
Cell Nucleus, Cerebral Cortex, Neurons, DNA, Superhelical, In Vitro Techniques, Rats, Kinetics, DNA Topoisomerases, Type I, Gamma Rays, Animals, Novobiocin
Cell Nucleus, Cerebral Cortex, Neurons, DNA, Superhelical, In Vitro Techniques, Rats, Kinetics, DNA Topoisomerases, Type I, Gamma Rays, Animals, Novobiocin
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