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Prevalence of Incompletely Penetrant Huntington's Disease Alleles Among Individuals With Major Depressive Disorder

descriptionPublicationkeyboard_double_arrow_right Article 01 May 2010 English Publisher:American Psychiatric Association PublishingJournal:American Journal of Psychiatry, volume 167, pages 574-579 (issn: 0002-953X, eissn: 1535-7228,

Authors: Shaun Purcell; Hans C. Breiter; Markus M. Nöthen; Wolfgang Maier; Maurizio Fava; Patrick F. Sullivan; Marcy E. MacDonald; +10 Authors

doi: 10.1176/appi.ajp.2009.09070973 , 10.17615/n96k-pw59

pmid: 20360314

pmc: PMC3114558

Prevalence of Incompletely Penetrant Huntington's Disease Alleles Among Individuals With Major Depressive Disorder

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Abstract

Presymptomatic individuals with the Huntingtin (HTT) CAG expansion mutation that causes Huntington’s disease may have higher levels of depressive symptoms than healthy comparison populations. However, the prevalence of HTT CAG repeat expansions among individuals diagnosed with major depressive disorder has not been established.

Related Organizations

Massachusetts General Hospital
United States
Harvard University
United States

Keywords

Adult, Male, Depressive Disorder, Major, Adolescent, Middle Aged, Polymerase Chain Reaction, Young Adult, Huntington Disease, Case-Control Studies, Humans, Female, Alleles, Repetitive Sequences, Nucleic Acid

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	51
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%